Arka Sutisno, seorang dokter kandungan zaman modern, mengalami kejadian tak terduga yang membuatnya transmigrasi ke masa lalu. Dia mendapati dirinya menjadi narapidana hukuman mati bersama kakak iparnya, hanya karena sang kakak ipar menolak menyerahkan bayinya untuk dijadikan bahan obat bagi Selir Agung.
Di tengah keputusasaan, pihak istana mengeluarkan pengumuman: siapa pun yang bisa membantu mengatasi masalah ASI Selir Agung yang tidak keluar akan diampuni dosanya dan diberikan jabatan. Mengandalkan keahlian medis profesionalnya, Arka pun mencabut pengumuman tersebut demi bertahan hidup.
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